Journal
JOINT BONE SPINE
Volume 76, Issue 1, Pages 10-14Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.jbspin.2008.08.002
Keywords
T lymphocytes; Rheumatoid arthritis; Immunomodulation; Cytokines; Cell therapy; Regulatory T lymphocytes
Categories
Funding
- French Society for Rheumatology
- Courtins Arthritis Foundation
- INSERM
- National Research Agency
- Abbott
- BMS
- Roche
- Sherring-Plough
- Wyeth
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Modulation of the T-cell response depends chiefly on regulatory T cells (Treg), which express CD4 and CD25. Some Treg cells are present naturally, whereas others are induced in response to antigens. The immunomodulating effects of Treg cells are mediated by membrane molecules (e.g., CTLA4, GITR, and OX40) and cytokines. IL-35 seems to be a crucial mediator, although IL-10 and TGF beta are also important. The role for Treg cells in rheumatoid arthritis (RA) has been established in both patients and animal models. Treg function is deficient in RA, whereas Treg counts vary. Treg counts increase in patients who are responding to TNF alpha antagonist therapy. Among current hypotheses, Treg expansion or transfer may hold promise for the treatment of RA. (C) 2008 Elsevier Masson SAS. All rights reserved.
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