Journal
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Volume 14, Issue 5, Pages 278-280Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RHU.0b013e3181886064
Keywords
Wegener granulomatosis; pediatric vasculitis; rituximab; refractory Wegener
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We describe a case of pediatric Wegener granulomatosis initially treated with cyclophosphamide and oral corticosteroids resulting in remission for 5 years. Of note in this case is relapse with severe pulmonary disease treated with multiple regimens, all unsuccessful. Patient achieved remission with rituximab infusion therapy. This demonstrates how rituximab may be beneficial for childhood-onset Wegener granulomatosis unresponsive to conventional therapy. The case is followed by a review of the current treatment options.
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