Journal
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Volume 14, Issue 3, Pages 166-168Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RHU.0b013e3181775e80
Keywords
hepatitis C; lupus; interferon; antiviral; autoimmune
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We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.
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