Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31
Volume 31, Issue -, Pages 575-591Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100814-125323
Keywords
lumenogenesis; epithelial; coalescence
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Funding
- NIDDK NIH HHS [R01 DK064380] Funding Source: Medline
- NIGMS NIH HHS [T32 GM08730, T32 GM008730] Funding Source: Medline
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One of the major challenges in biology is to explain how complex tissues and organs arise from the collective action of individual polarized cells. The best-studied model of this process is the cross talk between individual epithelial cells during their polarization to form the multicellular epithelial lumen during tissue morphogenesis. Multiple mechanisms of apical lumen formation have been proposed. Sonic epithelial lumens form from preexisting polarized epithelial structures. However, de novo lumen formation from nonpolarized cells has recently emerged as an important driver of epithelial tissue morphogenesis, especially during the formation of small epithelial tubule networks. In this review, we discuss the latest findings regarding the mechanisms and regulation of de novo lumen formation in vitro and in vivo.
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