Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 31
Volume 31, Issue -, Pages 741-777Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100913-013020
Keywords
dendrite; self-avoidance; tiling; synapse formation; neural development
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Funding
- NEI NIH HHS [R01 EY022073, 1R01EY024694] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY024694, R01EY022073] Funding Source: NIH RePORTER
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The nervous system is populated by numerous types of neurons, each bearing a dendritic arbor with a characteristic morphology. These type-specific features influence many aspects of a neuron's function, including the number and identity of presynaptic inputs and how inputs are integrated to determine firing properties. Here, we review the mechanisms that regulate the construction of cell type specific dendrite patterns during development. We focus on four aspects of dendrite patterning that are particularly important in determining the function of the mature neuron: (a) dendrite shape, including branching pattern and geometry of the arbor; (b) dendritic arbor size; (c) targeting of dendrites to particular locations; and (d) subdivision of dendrites into compartments with unique electrical properties or synaptic inputs.
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