Journal
JAPANESE JOURNAL OF OPHTHALMOLOGY
Volume 57, Issue 5, Pages 440-446Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10384-013-0251-y
Keywords
Diquafosol; Dry eye; Treatment; Tear film
Categories
Funding
- Japanese Ministry of the Education, Culture, Sports, Science and Technology [22791659]
- Grants-in-Aid for Scientific Research [22791659] Funding Source: KAKEN
Ask authors/readers for more resources
To evaluate the preliminary long-term efficacy of diquafosol ophthalmic solution for aqueous-deficient dry eye. Fifteen patients with mild-to-moderate aqueous-deficient dry eye were enrolled. After a washout period, the patients were treated with 3 % diquafosol ophthalmic solution for 6 months. We assessed 12 subjective dry eye symptoms, corneal and conjunctival staining with fluorescein, tear film break-up time (BUT), lower tear meniscus height measured with anterior-segment optical coherence tomography, Schirmer's testing, and adverse reactions at baseline and 1, 3, and 6 months after the start of treatment. Treatment with diquafosol ophthalmic solution significantly improved dry eye symptoms, corneal staining, BUT, and tear meniscus height at 1 month and maintained the effectiveness for 6 months. Conjunctival staining significantly improved 3 and 6 months after treatment. No significant adverse reactions developed. Prolonged use of diquafosol ophthalmic solution for 6 months produced significant improvement both subjectively (dry eye symptom score) and objectively (ocular staining score and tear function tests) for aqueous-deficient dry eye.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available