Journal
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Volume 38, Issue 12, Pages 857-860Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jjco/hyn110
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Funding
- Japanese Ministry of Health, Labor and Welfare [15-23]
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Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatits pain. However, these observations will need to be further confirmed in a randomized-controlled trial.
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