Journal
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 17
Volume 17, Issue -, Pages 385-414Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071114-040723
Keywords
PET/CT; PET/MRI; silicon photomultipliers; system model; tomographic image reconstruction; multimodality kinetic modeling
Categories
Funding
- NATIONAL CANCER INSTITUTE [U01CA148131, R01CA160253, R01CA169072, R01CA042593, R01CA164371] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA160253, R01CA164371, R01CA169072, U01 CA148131, R01 CA169072, R01CA160253, R01 CA042593, U01-CA148131, R01-CA042593, R01 CA164371] Funding Source: Medline
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Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positronemitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.
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