Journal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84
Volume 84, Issue -, Pages 325-354Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-080111-092106
Keywords
ribonucleoproteins; RNA processing; coupling; mRNP packaging; RNP remodeling; RNA granules
Categories
Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG004659, U54HG007005] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM053007] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS075449] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NHGRI NIH HHS [HG004659, U54HG007005, U54 HG007005, R01 HG004659] Funding Source: Medline
- NIGMS NIH HHS [R01 GM053007, GM53007] Funding Source: Medline
- NINDS NIH HHS [R01 NS075449, NS075449] Funding Source: Medline
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Throughout their lifetimes, messenger RNAs (mRNAs) associate with proteins to form ribonucleoproteins (mRNPs). Since the discovery of the first mRNP component more than 40 years ago, what is known as the mRNA interactome now comprises > 1,000 proteins. These proteins bind mRNAs in myriad ways with varying affinities and stoichiometries, with many assembling onto nascent RNAs in a highly ordered process during transcription and precursor mRNA (pre-mRNA) processing. The nonrandom distribution of major mRNP proteins observed in transcriptome-wide studies leads us to propose that mRNPs are organized into three major domains loosely corresponding to 5' untranslated regions (UTRs), open reading frames, and 3' UTRs. Moving from the nucleus to the cytoplasm, mRNPs undergo extensive remodeling as they are first acted upon by the nuclear pore complex and then by the ribosome. When not being actively translated, cytoplasmic mRNPs can assemble into large multi-mRNP assemblies or be permanently disassembled and degraded. In this review, we aim to give the reader a thorough understanding of past and current eukaryotic mRNP research.
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