Synthesis of new pyrazole derivatives via multicomponent reaction and evaluation of their antimicrobial and antioxidant activities

This work describes a facile synthesis and characterization of a new series of pyrazole containing pyrimidine, 1,4-dihydropyridine, and imidazole derivatives using substituted 4-formylpyrazole as a key intermediate via multicomponent reaction sequence. The structures of these unknown compounds were elucidated by IR, H-1 NMR, C-13 NMR, LC-MS, and elemental analysis. The synthesized products were screened for their in vitro antimicrobial and antioxidant properties. Among the tested 3-(3,4-dihalophenyl)-1-phenyl-1H-pyrazol-4-yl, incorporated acetyl dihydropyrimidine compounds exhibited promising antimicrobial activity and DPPH radical scavenging activity with levels of inhibition at 89.4 and 83.3 %, respectively.