Journal
MOLECULES AND CELLS
Volume 38, Issue 11, Pages 991-997Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.14348/molcells.2015.0197
Keywords
apoptosis; glioma; resveratrol; TTP; uPA; uPAR
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Funding
- National Research Foundation of Korea (NRF)
- Korean Government (MEST) [2013R1A2A2A01068964]
- National Research Foundation of Korea [2013R1A2A2A01068964] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Tristetraprolin (TTP) is an AU-rich elements (AREs)binding protein, which regulates the decay of AREs-containing mRNAs such as proto-oncogenes, antiapoptotic genes and immune regulatory genes. Despite the low expression of TTP in various human cancers, the mechanism involving suppressed expression of TTP is not fully understood. Here, we demonstrate that Resveratrol (3,5,4'-trihydroxystilbene, Res), a naturally occurring compound, induces glioma cell apoptosis through activation of tristetraprolin (TTP). Res increased TTP expression in U87MG human glioma cells. Res-induced TTP destabilized the urokinase plasminogen activator and urokinase plasminogen activator receptor mRNAs by binding to the ARE regions containing the 3' untranslated regions of their mRNAs. Furthermore, TTP induced by Res suppressed cell growth and induced apoptosis in the human glioma cells. Because of its regulation of TTP expression, these findings suggest that the bioactive dietary compound Res can be used as a novel anti-cancer agent for the treatment of human malignant gliomas.
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