Journal
MOLECULES
Volume 20, Issue 8, Pages 14860-14878Publisher
MDPI
DOI: 10.3390/molecules200814860
Keywords
PSMA; prostate cancer; PET; CT; Ga-68-HBED-CC-(Ahx)Lys-NH-CO-NH-Glu; Ga-68-DKFZ-PSMA-11; Ga-68-PSMA(HBED)
Funding
- Department of Science and Technology
- South African Nuclear Energy Corporation
- Nuclear Technologies in Medicine
- Biosciences Initiative
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Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly expressed in almost all prostate cancers. By playing such a universal role in the disease, PSMA provides a target for diagnostic imaging of prostate cancer using positron emission tomography/computed tomography (PET/CT). The PSMA-targeting ligand Glu-NH-CO-NH-Lys-(Ahx)-HBED-CC (DKFZ-PSMA-11) has superior imaging properties and allows for highly-specific complexation of the generator-based radioisotope Gallium-68 (Ga-68). However, only module-based radiolabeling procedures are currently available. This study intended to develop a single vial kit solution to radiolabel buffered DKFZ-PSMA-11 with Ga-68. A Ge-68/Ga-68-generator was utilized to yield (GaCl3)-Ga-68 and major aspects of the kit development were assessed, such as radiolabeling performance, quality assurance, and stability. The final product was injected into patients with prostate cancer for PET/CT imaging and the kit performance was evaluated on the basis of the expected biodistribution, lesion detection, and dose optimization. Kits containing 5 nmol DKFZ-PSMA-11 showed rapid, quantitative Ga-68-complexation and all quality measurements met the release criteria for human application. The increased precursor content did not compromise the ability of Ga-68-DKFZ-PSMA-11 PET/CT to detect primary prostate cancer and its advanced lymphatic- and metastatic lesions. The Ga-68-DKFZ-PSMA-11 kit is a robust, ready-to-use diagnostic agent in prostate cancer with high diagnostic performance.
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