Journal
MOLECULES
Volume 20, Issue 10, Pages 18001-18015Publisher
MDPI
DOI: 10.3390/molecules201018001
Keywords
Citrullus colocynthis; cucurbitacins; cytotoxicity
Funding
- Tunisian National Ministry of Higher Education and Scientific Research, University of Toulouse 3
- French-Tunisian Hubert Curien Partnership Utique [12G0821]
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Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.
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