Journal
MOLECULES
Volume 20, Issue 8, Pages 13642-13658Publisher
MDPI
DOI: 10.3390/molecules200813642
Keywords
asymmetric organocatalysis; BrOnsted base; cinchona alkaloids; butenolides; 1-azadienes; diastereodivergence
Funding
- NSFC [21302221]
Ask authors/readers for more resources
An asymmetric annulation reaction of -butenolides and cyclic 1-azadienes containing a 1,2-benzoisothiazole-1,1-dioxide motif has been studied, proceeding in a tandem Michael addition-aza-Michael addition sequence. Endo-type cycloadducts bearing fused tetracyclic skeletons were isolated in fair yields and with high enantioselectivity (up to >99% ee) under the catalysis of modified cinchona alkaloid (DHQD)(2)PHAL. Besides, exo-type diastereomers could be produced using -isocupreidine (-ICD) as the catalyst, though with moderate enantioselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available