Journal
MOLECULES
Volume 20, Issue 9, Pages 16643-16671Publisher
MDPI
DOI: 10.3390/molecules200916643
Keywords
aptamers; modified nucleoside triphosphates; polymerases; SELEX; therapeutic oligonucleotides; chemically modified nucleic acids; synthetic genetic polymers
Funding
- Swiss National Science Foundation [PZ00P2_126430/1, PZ00P2_144595]
- Swiss National Science Foundation (SNF) [PZ00P2_126430, PZ00P2_144595] Funding Source: Swiss National Science Foundation (SNF)
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The enzymatic co-polymerization of modified nucleoside triphosphates (dN*TPs and N*TPs) is a versatile method for the expansion and exploration of expanded chemical space in SELEX and related combinatorial methods of in vitro selection. This strategy can be exploited to generate aptamers with improved or hitherto unknown properties. In this review, we discuss the nature of the functionalities appended to nucleoside triphosphates and their impact on selection experiments. The properties of the resulting modified aptamers will be described, particularly those integrated in the fields of biomolecular diagnostics, therapeutics, and in the expansion of genetic systems (XNAs).
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