Journal
MOLECULES
Volume 20, Issue 8, Pages 14051-14081Publisher
MDPI
DOI: 10.3390/molecules200814051
Keywords
viral infections; antiviral therapy; nanomaterials
Funding
- Centre National de la Recherche Scientifique (CNRS)
- Lille1 University
- Nord Pas de Calais region
- Institut Universitaire de France (IUF)
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Multivalent interactions are omnipresent in biology and confer biological systems with dramatically enhanced affinities towards different receptors. Such multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers, and liposomes have successfully targeted pathogenic interactions. While a high synthetic effort was often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules. This review article will summarize the different nanoparticle-based approaches currently available for the treatment of viral infections.
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