Journal
MOLECULES
Volume 21, Issue 1, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules21010045
Keywords
Schmidt reaction; aldehydes; nitriles; HFIP
Funding
- University of Kansas
Ask authors/readers for more resources
The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available