Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 67, Issue 3, Pages E88-E93Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000000309
Keywords
tuberculosis; HIV; AIDS; Xpert MTB; RIF assay; diagnostic testing; South Africa
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Funding
- Fogarty International Clinical Research Scholars and Fellows Program at Vanderbilt University [R24 TW007988]
- Harvard Global Health Institute
- The Program for AIDS Clinical Research Training [T32 AI007433]
- National Institute of Mental Health [R01 MH090326]
- NCATS/NIH [UL1TR000011]
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Setting:We conducted a retrospective study among HIV-infected adult suspects (18 years) with pulmonary tuberculosis (TB), who underwent Xpert MTB/RIF (Xpert) testing at McCord Hospital and its adjoining HIV clinic in Durban, South Africa.Objective:To determine if Xpert testing performed at a centralized laboratory accelerated time to TB diagnosis.Design:We obtained data on sputum smear microscopy [acid-fast bacilli (AFB)], Xpert, and the rationale for treatment initiation from medical records. The primary outcome was total diagnostic time, defined as time from sputum collection to clinicians' receipt of results. A linear mixed-effect model compared the duration of steps in the diagnostic pathway across testing modalities.Results:Among 403 participants, the median total diagnostic time for AFB and Xpert was 3.3 and 6.4 days, respectively (P < 0.001). When compared with AFB, the median delay for Xpert laboratory processing was 1.4 days (P < 0.001) and result transfer to clinic was 1.7 days (P < 0.001). Among 86 Xpert-positive participants who initiated treatment, 49 (57%) started treatment based on clinical suspicion or AFB-positive results, whereas only 32 (37%) started treatment based on Xpert-positive results.Conclusions:In our setting, Xpert results took twice as long as AFB results to reach clinicians. Replacing AFB with centralized Xpert may delay TB diagnoses in some settings.
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