Journal
MOLECULES
Volume 20, Issue 11, Pages 19984-20013Publisher
MDPI AG
DOI: 10.3390/molecules201119673
Keywords
1,2,3-triazoloamide; solid-phase synthesis; solution-phase synthesis
Funding
- National Research Foundation of Korea (NRF) from the Basic Science Research Program, the Ministry of Science, ICT and Future Planning, Republic of Korea [NRF-2014R1A1A1037635, NRF-2014R1A2A1A11052798]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI11C1300(A111345)]
Ask authors/readers for more resources
Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A secondary -1,2,3-triazoloamide library was constructed and expanded by a previously developed solid-phase synthetic route and a tertiary 1,2,3-triazoloamide library was constructed by a parallel solution-phase synthetic route. The synthetic routes rely on amide formation with secondary amines and chloro-acid chlorides; S(N)2 reaction with sodium azide; and the selective [3 + 2] Huisgen cycloaddition with appropriate terminal alkynes. The target secondary and tertiary 1,2,3-triazoloamide derivatives were obtained with three-diversity points in excellent overall yields and purities using the reported solid- and solution-phase synthetic routes, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available