Journal
MOLECULES
Volume 20, Issue 11, Pages 20063-20078Publisher
MDPI
DOI: 10.3390/molecules201119676
Keywords
sulphonylurea; antihyperglycemic agents; glucosamine; streptozocine
Funding
- Deanship of the Scientific Research, The University of Jordan [1532, 1541]
- Hamdi Mango Center for Scientific Research
- Daniel Turnberg Fellowship committee
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Sulphonylurea compounds have versatile activities such as antidiabetic, diuretic, herbicide, oncolytic, antimalarial, antifungal and anticancer. The present study describes the design, synthesis and in vivo testing of novel glycosylated aryl sulfonylurea compounds as antihyperglycaemic agents in streptozocine-induced diabetic mice. The rational for the introduction of the glucosamine moiety is to enhance selective drug uptake by pancreatic -cells in order to decrease the cardiotoxic side effect commonly associated with sulfonylurea agents. 2-Deoxy-2-(4-chlorophenylsulfonylurea)-d-glucopyranose was found to be the most potent antihyperglycaemic agents among the synthesized compounds in diabetic mice. This investigation indicates the importance of this novel class as potential antihyperglycaemic agents.
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