Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 56, Issue 4, Pages 340-343Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e31820bf84c
Keywords
CD4; gastrointestinal tract; HIV; IL-2; mucosa
Categories
Funding
- NIH, NIAID
- Critical Care Medicine Department
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
Ask authors/readers for more resources
We sought to determine the effects of interleukin-2 administered in combination with antiretroviral therapy (ART) on CD4(+) T cells in the gut. Lymphocytes from whole blood, colon, and terminal ileum of HIV-infected adults treated with interleukin-2 and ART or ART alone were examined. There were no differences between groups in the proportion of CD4(+) T cells or in expression of CD25 or Ki67 by CD4(+) T cells in the gut. Although IL-2 administration leads to expansion of peripheral blood CD4(+) T cells, there is no alteration in the proportion or activation of CD4(+) T cells in the gut mucosa.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available