Journal
MOLECULES
Volume 20, Issue 8, Pages 13854-13863Publisher
MDPI
DOI: 10.3390/molecules200813854
Keywords
Amarylidaceae alkaloids; antiproliferative activity; SAR
Funding
- Spanish MINECO [SAF2012-37344-C03-C01]
- Instituto de Salud Carlos III [PI11/00840]
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The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.
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