Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 51, Issue 4, Pages 399-406Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e3181acb4e5
Keywords
HIV; mortality; non-AIDS mortality; women; viral hepatitis
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Funding
- NCRR NIH HHS [UL1 RR024131] Funding Source: Medline
- NIAID NIH HHS [U01 AI042590, U01 AI034994, U01 AI035004, U01 AI031834, U01 AI034993-15, U01 AI034993, UO1-AI-34989, UO1-AI-35004, UO1-AI-34993, U01 AI034989, UO1-AI-31834, UO1-AI-42590, UO1-AI-34994] Funding Source: Medline
- NICHD NIH HHS [UO1-HD-23632, U01 HD032632] Funding Source: Medline
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Background: To assess trends in mortality and cause of death for women with HIV, we Studied deaths over a 10-year period among participants in the Women's Interagency HIV Study, a representative US cohort. Methods: Deaths were ascertained by National Death Index Plus match, and causes of death determined by death certificate. Results: From 1995 through 2004, 710 of 2792 HIV-infected participants died. During this interval, the standardized mortality ratio fell from a high of 24.7 in 1996 to a plateau with a mean of 10.3 from 2001 to 2004. Over the decade, deaths from non-AIDS causes increased and accounted for the majority of deaths by 2001-2004. The most common non-AIDS causes of death were trauma or overdose, liver disease, cardiovascular disease, and malignancy. Independent predictors of mortality besides HIV-associated variables were depressive symptoms and active hepatitis B or C. Women who were overweight or obese were significantly less likely to die of AIDS than women of normal weight. Conclusions: In the Women's Interagency HIV Study, the death rate has plateaued in recent years. Although HIV-associated factors predicted AIDS and non-AIDS deaths, other treatable conditions predicted mortality. Further gains in reducing mortality among HIV-infected women may require broader access to therapies for depression, viral hepatitis, and HIV itself.
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