Journal
JACC-CARDIOVASCULAR INTERVENTIONS
Volume 1, Issue 5, Pages 469-479Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcin.2008.08.002
Keywords
angina pectoris; randomized trial; long-term prognosis
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Funding
- Japanese Ministry of Health, Labour, and Welfare
- Japan Heart Foundation (Tokyo, Japan)
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Objectives This study sought to determine whether initial medical therapy (MT) only or percutaneous coronary intervention plus medical therapy (PCI+MT) is better for patients with low-risk stable coronary artery disease (CAD) indicated for intervention in Japan. Background Several multicenter studies have suggested that in the above patients, an initial management strategy of PCI+MT does not reduce the long-term risk of cardiovascular events more effectively than initial MT only. Methods We conducted a randomized comparative study (JSAP [Japanese Stable Angina Pectoris] study) in the previously mentioned patients. Results The patients were randomized to PCI+MT (n = 192) or initial MT only group (n = 192), and the patient characteristics were very similar in the 2 groups. During the 3.3-year follow-up, there was no significant difference in the cumulative death rate between PCI+MT (2.9%) and MT (3.9%). However, the cumulative risk of death plus acute coronary syndrome was significantly smaller in PCI+MT. Conclusions In stable low-risk CAD, PCI+MT may improve long-term prognosis more effectively than MT. (J Am Coll Cardiol Intv 2008;1:469-79) (C) 2008 by the American College of Cardiology Foundation
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