4.6 Article

Selective Halogen-Lithium Exchange of 1,2-Dihaloarenes for Successive [2+4] Cycloadditions of Arynes and Isobenzofurans

Journal

MOLECULES
Volume 20, Issue 10, Pages 19449-19462

Publisher

MDPI
DOI: 10.3390/molecules201019449

Keywords

aryne; isobenzofuran; [2+4] cycloaddition; 1; 2-dihaloarenes; polyacene; halogen-lithium exchange

Funding

  1. MEXT, Japan [2707]
  2. ACT-C from the Japan Science and Technology Agency
  3. Grants-in-Aid for Scientific Research [15H05840] Funding Source: KAKEN

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Successive [2+4] cycloadditions of arynes and isobenzofurans by site-selective halogen-lithium exchange of 1,2-dihaloarenes were developed, allowing the rapid construction of polycyclic compounds which serve as a useful synthetic intermediates for the preparation of various polyacene derivatives.

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