Journal
MOLECULES
Volume 20, Issue 5, Pages 7940-7950Publisher
MDPI
DOI: 10.3390/molecules20057940
Keywords
Xylaria sp; cryptic natural product; cytochalasin; -pyrone; xylapyrones; cytotoxicity
Funding
- National Natural Science Foundation of China [31100080, 21272136]
- Science Foundation of China Three Gorges Universtiy [KJ2011B003, KJ2014B021]
- Yichang Science Research and Development Project [A13301-56]
- Education Department of Hubei Province Key Project [D20141201]
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Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1-5 to six new -pyrone derivatives, xylapyrones A-F (compounds 6-11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1-3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 M and compounds 4-11 were found to be inactive, with IC50 values >100 M.
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