Journal
MOLECULES
Volume 20, Issue 9, Pages 15572-15588Publisher
MDPI AG
DOI: 10.3390/molecules200915572
Keywords
Juglans mandshurica Maxim; green walnut husks; naphthoquinones; cytotoxic activity; structure-activity relationships
Funding
- National Science Foundation [81202890]
- China Postdoctoral Science Foundation [2013M530164/2014T70374]
- Heilongjiang Postdoctoral Fund [LBH-Z13195]
- Harbin city youth science and technology innovation talents [2013RFQXJ052]
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Twenty-seven naphthoquinones and their derivatives, including four new naphthalenyl glucosides and twenty-three known compounds, were isolated from green walnut husks, which came from Juglans mandshurica Maxim. The structures of four new naphthalenyl glucosides were elucidated based on extensive spectroscopic analyses. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by MTT [3-(4,5-dimethylthiazo l-2-yl)-2,5 diphenyl tetrazolium bromide] assay. The results were shown that most naphthoquinones in an aglycone form exhibited better cytotoxicity in vitro than naphthalenyl glucosides with IC50 values in the range of 7.33-88.23 M. Meanwhile, preliminary structure-activity relationships for these compounds were discussed.
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