Journal
IUBMB LIFE
Volume 66, Issue 5, Pages 318-326Publisher
WILEY
DOI: 10.1002/iub.1272
Keywords
Endoplasmic reticulum; chaperone; protein quality control; protein folding
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Endoplasmic reticulum (ER) is an essential sub-cellular compartment of the eukaryotic cell performing many diverse functions essential for the cell and the whole organism. ER molecular chaperones and folding enzymes are multidomain proteins that are designed to support nascent proteins entering ER lumen to achieve their native conformation, mediate post-translational modification, prevent misfolded protein aggregation, and facilitate exit from the ER. Typically the role of ER chaperones expands beyond protein folding. Here, we illustrate the multifunctional nature of many ER associated molecular chaperones and folding enzymes and unique functional overlap of these proteins all designed to support the many functions of the ER membrane. (C) 2014
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