Journal
IUBMB LIFE
Volume 63, Issue 4, Pages 248-257Publisher
WILEY-BLACKWELL
DOI: 10.1002/iub.448
Keywords
CETP; atherosclerosis; Alzheimer disease; inflammation; obesity
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Instituto Nacional de Ciencia e Tecnologia em Obesidade e Diabetes (INCT/CNPq/Fapesp)
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Cholesteryl ester transfer protein (CETP) exerts a profound impact on high-density lipoprotein (HDL) metabolism and, consequently, on the risk of atherosclerosis development and cardiovascular mortality. Here, we review the complex relationship between CETP and atherosclerosis based upon the experimental, clinical, and epidemiological studies. In addition, we discuss the recent findings that expand the functions of CETP to new areas of interest such as Alzheimer's disease, inflammation, and obesity. (C) 2011 IUBMB IUBMB Life, 63(4): 248-257, 2011
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