Journal
IUBMB LIFE
Volume 64, Issue 3, Pages 209-214Publisher
WILEY-BLACKWELL
DOI: 10.1002/iub.599
Keywords
APC; protein transport; nucleus; centrosome; mitochondria
Categories
Funding
- National Health and Medical Research Council of Australia
- Australian Research Council
- Cancer Council of New South Wales
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Genetic mutations of adenomatous polyposis coli (APC) predispose to high risk of human colon cancer. APC is a large tumor suppressor protein and truncating mutations disrupt its normal roles in regulating cell migration, DNA replication/repair, mitosis, apoptosis, and turnover of oncogenic beta-catenin. APC is targeted to multiple subcellular sites, and here we discuss recent evidence implicating novel protein interactions and functions of APC in the nucleus and at centrosomes and mitochondria. The ability of APC to shuttle between these and other cell locations is hypothesized to be integral to its cellular function. (c) 2011 IUBMB IUBMB Life, 2011
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