Journal
IUBMB LIFE
Volume 62, Issue 2, Pages 140-157Publisher
WILEY
DOI: 10.1002/iub.300
Keywords
signal transduction; signalling; drug discovery
Categories
Funding
- Cancer Research UK
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Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c-Myc. Alternatively they can negatively regulate ubiquitin-dependent signalling cascades such as the NF-kappa B activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. (C) 2009 IUBMB IUBMB Life, 62(2): 140-157, 2010
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