Journal
IUBMB LIFE
Volume 60, Issue 3, Pages 145-153Publisher
WILEY
DOI: 10.1002/iub.21
Keywords
skeletal muscle; AMPK; glucose uptake; training adaptation; exercise
Categories
Funding
- NIAMS NIH HHS [F32 AR051663-02, R01 AR045670, R01AR45670, F32 AR051663, R01 AR045670-10, F32AR051663] Funding Source: Medline
- NIDDK NIH HHS [R01 DK068626, P30 DK036836, R01DK068626, P30 DK036836-21, DK36836, R01 DK068626-04] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [F32AR051663, R01AR045670] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068626, P30DK036836] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Physical activity elicits physiological responses in skeletal muscle that result in a number of health benefits, in particular in disease states, such as type 2 diabetes. An acute bout of exercise/muscle contraction improves glucose homeostasis by increasing skeletal muscle glucose uptake, while chronic exercise training induces alterations in the expression of metabolic genes, such as those involved in muscle fiber type, mitochondrial biogenesis, or glucose transporter 4 (GLUT4) protein levels. A primary goal of exercise research is to elucidate the mechanisms that regulate these important metabolic and transcriptional events in skeletal muscle. In this review, we briefly summarize the current literature describing the molecular signals underlying skeletal muscle responses to acute and chronic exercise. The search for possible exercise/contraction-stimulated signaling proteins involved in glucose transport, muscle fiber type, and mitochondrial biogenesis is ongoing. Further research is needed because full elucidation of exercise-mediated signaling pathways would represent a significant step toward the development of new pharmacological targets for the treatment of metabolic diseases such as type 2 diabetes. (C) 2008 IUBMB.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available