Journal
IUBMB LIFE
Volume 60, Issue 4, Pages 232-235Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/iub.38
Keywords
selenoprotein biosynthesis; selenium; selenoprotein
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Selenium is an essential micronutrient that has been linked to various aspects of human health. Selenium exerts its biological activity through the incorporation of the amino acid, selenocysteine (See), into a unique class of proteins termed selenoproteins. See incorporation occurs cotranslationally at UGA codons in archaea, prokaryotes, and eukaryotes. UGA codons specify See coding rather than termination by the presence of specific secondary structures in mRNAs termed selenocysteine insertion (SECIS) elements, and trans-acting factors that associate with SECIS elements. Herein, we discuss the various proteins known to function in eukaryotic selenoprotein biosynthesis, including several players whose roles have only been elucidated very recently. (c) 2008 IUBMB.
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