Journal
IUBMB LIFE
Volume 60, Issue 12, Pages 818-823Publisher
WILEY
DOI: 10.1002/iub.131
Keywords
lumican; small leucine-rich repeat proteoglycans (SLRP); cellular functions; extracellular matrix; matrikine
Categories
Ask authors/readers for more resources
Lumican belongs to the family of small leucine-rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of lumican has been correlate to the growth and metastasis of various malignancies; however, its exact role in tumorogenesis remains elusive. This review focuses upon the role of lumican in cell biology, providing insights into molecular mechanisms that lumican likely utilizes to control processes relevant to tumorogenesis. (C) 2008 IUBMR
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available