Journal
ISRAEL JOURNAL OF CHEMISTRY
Volume 53, Issue 8, Pages 530-554Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.201300046
Keywords
amphiphiles; nanostructures; peptides; self-assembly; supramolecular chemistry
Categories
Funding
- National Institute of Dental and Craniofacial Research (NIDCR) [5R01DE015920]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) [5R01EB003806]
- National Institutes of Health
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE015920] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Peptide nanostructures are an exciting class of supramolecular systems that can be designed for novel therapies with great potential in advanced medicine. This paper reviews progress on nanostructures based on peptide amphiphiles capable of forming one-dimensional assemblies that emulate in structure the nanofibers present in extracellular matrices. These systems are highly tunable using supramolecular chemistry, and can be designed to signal cells directly with bioactive peptides. Peptide amphiphile nanofibers can also be used to multiplex functions through co-assembly and designed to deliver proteins, nucleic acids, drugs, or cells. We illustrate here the functionality of these systems, describing their use in regenerative medicine of bone, cartilage, the nervous system, the cardiovascular system, and other tissues. In addition, we highlight recent work on the use of peptide amphiphile assemblies to create hierarchical biomimetic structures with order beyond the nanoscale, and also discuss the future prospects of these supramolecular systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available