Journal
ISRAEL JOURNAL OF CHEMISTRY
Volume 53, Issue 8, Pages 577-587Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.201300025
Keywords
high-throughput screening; inhibitors; supramolecular; TTSS; T3SS
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Funding
- National Institute of General Medical Sciences Postdoctoral Fellowship [GM099248-01]
- Center for Molecular Analysis and Design (CMAD) at Stanford University
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The TypeIII Secretion System (TTSS) is indispensable for virulence of many Gram-negative pathogenic bacteria, including Escherichia coli, Salmonella spp., Yersinia spp., Vibrio spp., Chlamydia spp., Shigella spp., Pseudomonas spp., Xanthomonas spp., and Auromonas spp. Such pathogenic bacteria are responsible for diseases such as plague, shigellosis, chlamydia, cholera, pneumonia, and gastroenteritis. This review offers insights into the known inhibitors of the TTSS, their discovery, and their mode of action.
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