Journal
ISRAEL JOURNAL OF CHEMISTRY
Volume 51, Issue 8-9, Pages 940-952Publisher
WILEY-BLACKWELL
DOI: 10.1002/ijch.201100076
Keywords
expressed protein ligation; membrane protein; native chemical ligation; protein chemical synthesis; solid-phase peptide synthesis
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The development of efficient chemical methods for total synthesis or semisynthesis of integral membrane proteins is an important challenge at the interface between chemistry and biology. This review outlines the recent advances in the synthesis of integral membrane proteins, with particular focus on the methods for difficult peptide synthesis, purification, and enhancement of peptide solubility under the ligation conditions. The applications of these methods to the synthesis of integral membrane proteins with one or multiple transmembrane domains are also described.
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