Journal
ISME JOURNAL
Volume 5, Issue 7, Pages 1178-1190Publisher
SPRINGERNATURE
DOI: 10.1038/ismej.2011.2
Keywords
cyanophage; gene transfer; metagenomics; photosynthesis; viral-host interactions
Categories
Funding
- Israel Science Foundation [1203/06]
- Academy of Finland [118637]
- CNRS [PEPS-2008]
- ARC (Association pour la Recherche contre le Cancer, Villejuif) [4920]
- National Science Foundation [DBI-0850206]
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0850206] Funding Source: National Science Foundation
- Office of Polar Programs (OPP)
- Directorate For Geosciences [1115245] Funding Source: National Science Foundation
- Office of Polar Programs (OPP)
- Directorate For Geosciences [1056396, 1041742] Funding Source: National Science Foundation
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Viral genomes often contain genes recently acquired from microbes. In some cases (for example, psbA) the proteins encoded by these genes have been shown to be important for viral replication. In this study, using a unique search strategy on the Global Ocean Survey (GOS) metagenomes in combination with marine virome and microbiome pyrosequencing-based datasets, we characterize previously undetected microbial metabolic capabilities concealed within the genomes of uncultured marine viral communities. A total of 34 microbial gene families were detected on 452 viral GOS scaffolds. The majority of auxiliary metabolic genes found on these scaffolds have never been reported in phages. Host genes detected in viruses were mainly divided between genes encoding for different energy metabolism pathways, such as electron transport and newly identified photosystem genes, or translation and post-translation mechanism related. Our findings suggest previously undetected ways, in which marine phages adapt to their hosts and improve their fitness, including translation and post-translation level control over the host rather than the already known transcription level control. The ISME Journal (2011) 5, 1178-1190; doi:10.1038/ismej.2011.2; published online 10 February 2011 Subject Category: integrated genomics and post-genomics approaches in microbial ecology
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