Journal
ISME JOURNAL
Volume 5, Issue 11, Pages 1735-1747Publisher
SPRINGERNATURE
DOI: 10.1038/ismej.2011.51
Keywords
microbial genomics; extreme environment; uncultured microorganism; bacterial phylum; synecology; functional ecology
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Funding
- French Ministry of Education and Research
- Agence Nationale de la Recherche (ANR)
- Universite de Strasbourg (UdS)
- Consortium National de Recherche en Genomique (CNRG)
- Centre National de la Recherche Scientifique (CNRS)
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By their metabolic activities, microorganisms have a crucial role in the biogeochemical cycles of elements. The complete understanding of these processes requires, however, the deciphering of both the structure and the function, including synecologic interactions, of microbial communities. Using a metagenomic approach, we demonstrated here that an acid mine drainage highly contaminated with arsenic is dominated by seven bacterial strains whose genomes were reconstructed. Five of them represent yet uncultivated bacteria and include two strains belonging to a novel bacterial phylum present in some similar ecosystems, and which was named 'Candidatus Fodinabacter communificans.' Metaproteomic data unravelled several microbial capabilities expressed in situ, such as iron, sulfur and arsenic oxidation that are key mechanisms in biomineralization, or organic nutrient, amino acid and vitamin metabolism involved in synthrophic associations. A statistical analysis of genomic and proteomic data and reverse transcriptase-PCR experiments allowed us to build an integrated model of the metabolic interactions that may be of prime importance in the natural attenuation of such anthropized ecosystems. The ISME Journal (2011) 5, 1735-1747; doi: 10.1038/ismej.2011.51; published online 12 May 2011
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