Journal
MOLECULAR PSYCHIATRY
Volume 21, Issue 3, Pages 437-443Publisher
SPRINGERNATURE
DOI: 10.1038/mp.2015.2
Keywords
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Funding
- UK Medical Research Council [G0901245, G0500079]
- US National Institutes of Health [HD044454, HD059215]
- Medical Research Council [G19/2]
- European Research Council [295366]
- MRC [G0901245, G0500079, G19/2] Funding Source: UKRI
- Medical Research Council [G19/2, G0901245, G0500079] Funding Source: researchfish
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One of the best predictors of children's educational achievement is their family's socioeconomic status (SES), but the degree to which this association is genetically mediated remains unclear. For 3000 UK-representative unrelated children we found that genome-wide single-nucleotide polymorphisms could explain a third of the variance of scores on an age-16 UK national examination of educational achievement and half of the correlation between their scores and family SES. Moreover, genome-wide polygenic scores based on a previously published genome-wide association meta-analysis of total number of years in education accounted for similar to 3.0% variance in educational achievement and similar to 2.5% in family SES. This study provides the first molecular evidence for substantial genetic influence on differences in children's educational achievement and its association with family SES.
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