Journal
MOLECULAR PSYCHIATRY
Volume 21, Issue 5, Pages 701-706Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2015.107
Keywords
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Funding
- National Institutes of Health, National Institute of Mental Health intramural program
- NIH [R01MH103716]
- Clinical Brain Disorders Branch
- Amy Deep-Soboslay of the National Institutes of Health, National Institute of Mental Health
- Lieber Institute
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Neurexin 1 (NRXN1), a presynaptic cell adhesion molecule, is implicated in several neurodevelopmental disorders characterized by synaptic dysfunction including autism, intellectual disability and schizophrenia. To gain insight into NRXN1's involvement in human cortical development we used quantitative real-time PCR to examine the expression trajectories of NRXN1, and its predominant isoforms, NRXN1-alpha and NRXN1-beta, in prefrontal cortex from fetal stages to aging. In addition, we investigated whether prefrontal cortical expression levels of NRXN1 transcripts are altered in schizophrenia or bipolar disorder in comparison with non-psychiatric control subjects. We observed that all three NRXN1 transcripts were highly expressed during human fetal cortical development, markedly increasing with gestational age. In the postnatal dorsolateral prefrontal cortex, expression levels were negatively correlated with age, peaking at birth until similar to 3 years of age, after which levels declined markedly to be stable across the lifespan. NRXN1-beta expression was modestly but significantly elevated in the brains of patients with schizophrenia compared with non-psychiatric controls, whereas NRXN1-alpha expression was increased in bipolar disorder. These data provide novel evidence that NRXN1 expression is highest in human dorsolateral prefrontal cortex during critical developmental windows relevant to the onset and diagnosis of a range of neurodevelopmental disorders, and that NRXN1 expression may be differentially altered in neuropsychiatric disorders.
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