Journal
INVESTIGATIVE RADIOLOGY
Volume 46, Issue 6, Pages 366-369Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLI.0b013e318209ed6f
Keywords
contrast enhancement; magnetic resonance imaging; calcium determination; gadobutrol; gadoxetate disodium
Funding
- Bayer HealthCare, Berlin, Germany
- Bayer HealthCare
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Objective: To determine the extent to which the gadolinium-containing contrast agents, gadobutrol (Gadovist) and gadoxetate disodium (Primovist/Eovist), interfere with the colorimetric measurement of calcium concentrations in serum and plasma. Materials and Methods: Gadobutrol and gadoxetate disodium were added in various concentrations to serum and plasma from healthy volunteers; the calcium concentration in these samples was then measured by standard colorimetry methods and atomic absorption. Results: At clinically relevant concentrations, neither gadobutrol nor gadoxetate disodium influenced the results of the calcium measurement in serum or plasma. Only at the highest concentrations tested (50 mM gadobutrol; 25 mM gadoxetate disodium), an effect was seen in some cases. Results were confirmed by atomic absorption spectroscopy as the reference method. Conclusions: At clinically relevant concentrations, gadobutrol and gadoxetate disodium did not interfere with standard colorimetric methods for calcium determination.
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