Journal
INVESTIGATIVE RADIOLOGY
Volume 43, Issue 12, Pages 843-853Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLI.0b013e3181893605
Keywords
DSCE-MRI; glioma grading; image processing; texture analysis; dynamic histogram analysis
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Objectives: (a.) The development of a novel analysis method, named Dynamic pixel intensity Histogram Analysis (DHA) allowing for pixel intensity-histogram-model-parameter fitting of arbitrary-shaped regions defined in dynamic-susceptibility-contrast-enhanced (DSCE) difference MR-image time-series, and (b) its prospective application and evaluation for glioma grading. Materials and Methods: For each difference-image, pixel intensity histograms of arbitrary-shaped ROIs were computed and fitted using the Levenberg-Marquardt algorithm. Time-dependent histogram center-position- and width-parameters are computed during bolus-passage. The method was applied to 25 patients with low and high grade gliomas. Results: During bolus outflow-time, histogram-center-position-parameter and histogram-width-parameter reach highest significance levels and discriminate gliomas of different grades. The histogram center-position-parameter discriminated grade-II from grade-III, grade-II from grade-IV but not grade-III from grade-IV. The observed histogram width-parameters discriminated grade-II from grade-III (P < 0.00022), grade-II from grade-IV (P < 8.3 10(-7)), and grade-III from grade-IV (P < 0.00063). Conclusions: DHA is a easy-to-use method for glioma grading; the histogram width parameter is best indicator for histologic grade.
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