Journal
INVESTIGATIONAL NEW DRUGS
Volume 33, Issue 2, Pages 480-489Publisher
SPRINGER
DOI: 10.1007/s10637-014-0189-z
Keywords
Sulforaphane; Prostate cancer; Biochemical recurrence
Categories
Funding
- Kuni Foundation
- Prostate Cancer Foundation
- Oregon Clinical and Translational Research Institute (OCTRI) from National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) [UL1TR000128, KL2TR000152]
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Diets high in cruciferous vegetables are associated with lower risk of incidence of prostate cancer, including aggressive forms of this disease. Human intervention studies with cruciferous vegetable-rich diets also demonstrate modulation of gene expression in important pathways in prostate cells. Sulforaphane is a constituent of these foods postulated to harbor the anti-neoplastic activity based on multiple tumor models. Our own work demonstrates that sulforaphane inhibits AR signaling in prostate cancer cells. Here, we report results from the first clinical trial of sulforaphane-rich extracts in men with prostate cancer. We treated 20 patients who had recurrent prostate cancer with 200 mu moles/day of sulforaphane-rich extracts for a maximum period of 20 weeks and determined the proportion of patients with a parts per thousand yen50 % PSA declines, the primary endpoint. Only one subject experienced a a parts per thousand yen50 % PSA decline. Thus, the primary endpoint was not achieved. Seven patients experienced smaller PSA declines (< 50 %). There was also a significant lengthening of the on-treatment PSA doubling time (PSADT) compared with the pre-treatment PSADT [6.1 months pre-treatment vs. 9.6 months on-treatment (p = 0.044)]. Finally, treatment with sulforaphane-rich extracts was safe with no Grade 3 adverse events. Treatment with 200 mu moles/day of sulforaphane-rich extracts did not lead to a parts per thousand yen50 % PSA declines in the majority of patients. However, because of the safety of treatment and the effects on PSADT modulation, further studies, including those with higher doses, may be warranted to clarify the role of sulforaphane as a prevention agent or treatment agent.
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