Journal
INVERTEBRATE REPRODUCTION & DEVELOPMENT
Volume 59, Issue -, Pages 39-44Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/07924259.2014.938196
Keywords
Hydra; FoxO; senescence; stem cells; piRNAs; longevity
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Funding
- National Institute on Aging [1R01AG037965-01]
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Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. Hydra maintains three stem cell lineages, used for continuous tissue morphogenesis and replacement. Recent work has elucidated the roles of the insulin/IGF-1 signaling target FoxO, of Myc proteins, and of PIWI proteins in Hydra stem cells. Under laboratory culture conditions, Hydra vulgaris show no signs of aging even under long-term study. In contrast, Hydra oligactis can be experimentally induced to undergo reproduction-associated senescence. This provides a powerful comparative system for future studies.
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