Journal
INTERVIROLOGY
Volume 57, Issue 6, Pages 353-356Publisher
KARGER
DOI: 10.1159/000366280
Keywords
Mouse mammary tumor virus; Human murine mammary tumor virus-like virus; Breast cancer
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Funding
- Tehran University of Medical Sciences [91-01-27-17276, 240/2174]
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Objective: The mouse mammary tumor virus (MMTV) is the well-established etiological agent of mammary tumors in mice. A series of studies have implicated that a human murine mammary tumor virus-like virus occurs in human breast cancer, but it is unclear whether it has any causal role. Methods: The aim of the present study was to investigate the presence of MMTV env gene-like sequences in a group of Iranian women with or without breast cancer. A total of 65 breast cancer and 65 noncancerous breast specimens from the Department of Pathology of Tabriz University in East Azerbaijan, Iran, were analyzed by nested PCR. Results: All breast cancer and benign breast samples were negative for MMTV env gene-like DNA. Conclusion: These results indicate that the MMTV env gene-like virus may not play a significant role in the etiology of breast cancer among Iranian women. (C) 2014 S. Karger AG, Basel.
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