Non-Invasive Evaluation of Hepatic Fibrosis for Type C Chronic Hepatitis

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography(R) (RTE) and transient elastography (FibroScan(R)) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis. Copyright (C) 2010 S. Karger AG, Basel