Journal
INTERNATIONAL UROGYNECOLOGY JOURNAL
Volume 20, Issue 5, Pages 515-522Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s00192-009-0822-0
Keywords
Bladder pain syndrome/interstitial cystitis (PBP/IC); cDNA microarray; Mast cell; Fc episilon RI; Allergic inflammation
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The aim of the study was to investigate the molecular signatures underlying bladder pain syndrome/interstitial cystitis (BPS/IC) using cDNA microarray. Microarray gene expression profiles are studied in a matched case-control studies by using a system of conditional regression modeling. Main findings are summarized as follows: Firstly, a 139-gene model was discovered to contain high expressions of bladder epithelium, which feature in BPS/IC. Secondly, complex metabolic reactions, including carbohydrate, lipid, cofactors, vitamins, xenobiotics, nucleotide, and amino acid metabolisms, are found to have a strong relationship with bladder smooth muscle contraction through IC status. Thirdly, we have found the transcriptional regulations of IC-induced bladder smooth muscle contraction status, including the level of contractile force, tissue homeostasis, energy homeostasis, and the development of nervous system. In addition, our study suggested the mast-cell activation mediated by the high-affinity receptor of Fc episilon RI triggering allergic inflammation through IC status. Such genetic changes, jointly termed bladder remodeling can constitute an important long-term consequence of phosphate-buffered saline (PBS)/IC. The success of this innovation has supported the use of microarray-based expression profiling as a single standardized platform for diagnosis of PBS/IC and offer drug discovery.
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