Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 31, Issue 2, Pages 119-132Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08830185.2012.664797
Keywords
B-cell receptor; kinase; leukemia; lymphoma; PCI-32765; X-linked agammaglobulinemia
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BTK is a kinase that functions downstream of multiple receptors in various hematologic cells. This review focuses on BTK-dependent pathways that are likely to be involved in maintaining the malignant phenotype in B-cell lymphomas and leukemias. Survival of various B-cell malignancies requires BTK-dependent signals from the B-cell antigen receptor. Survival is also dependent on malignant cells homing to and interacting with lymphoid microenvironments, and these interactions are also BTK-dependent due its role in signaling downstream of chemokine and innate immune receptors. The potential for therapeutic targeting of BTK is currently being tested in clinical settings.
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