Journal
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 29, Issue 4, Pages 403-420Publisher
INFORMA HEALTHCARE
DOI: 10.3109/08830185.2010.496503
Keywords
follicular T helper cells; B cells; germinal centers; T cell subsets
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Funding
- Department of Biotechnology (DBT)
- Council of Scientific and Industrial Research (CSIR), NewDelhi
- CSIR
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The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.
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